CXCL13

Across TCGA pan-cancer cohorts, CXCL13 RNA is linked to patient survival in 26 of 34 cancer types, making it the most broadly survival-associated CXCL13 data layer compared with 2 for mutation status and 5 for mass-spec protein.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher CXCL13 RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated CXCL13 expression acts as an unfavorable survival marker, although some lineages such as HNSC and SKCM show a favorable association.

HNSC, SKCM, and UVM are the cancer types where CXCL13 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	IV	0.727	0.554	<.001	127	view →
SKCM	OS	Median	All	0.428	0.259	<.001	126	view →
UVM	DFS	Median	II,III,IV	0.392	0.817	<.001	87	view →
KIRP	DFS	Tertile	All	0.737	0.923	<.001	85	view →
OV	OS	Quartile	II,III,IV	0.484	0.295	<.001	80	view →
CESC	DFS	Tertile	All	0.839	0.655	.002	64	view →
STAD	OS	Tertile	III,IV	0.740	0.525	.002	64	view →
BRCA	DFS	Tertile	All	0.603	0.469	<.001	60	view →
BLCA	OS	Quartile	III,IV	0.757	0.584	.007	53	view →
KIRC	DFS	Tertile	All	0.730	0.880	<.001	33	view →
ESCA	DFS	Median	III,IV	0.437	0.233	.003	27	view →
COAD	OS	Tertile	II,III,IV	0.899	0.551	.005	26	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 26 lineages.

CXCL13–HNSC (DFS)

Open the HNSC breakdown →