CXCL13

Across TCGA pan-cancer cohorts, CXCL13 RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of CXCL13’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where CXCL13 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types CXCL13 is over-expressed in tumor, although a few such as COAD and PRAD show the opposite, repressed pattern.

HNSC, KIRC, and LUAD are the cancer types where CXCL13 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in CXCL13 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	All	+2.364	<.001	12	view →
KIRC	Male	IV	+2.667	<.001	11	view →
LUAD	Female	All	+3.465	<.001	9	view →
COAD	All	II,III,IV	−1.580	<.001	8	view →
STAD	Female	All	+4.004	<.001	6	view →
LUSC	All	II,III,IV	+2.927	<.001	6	view →
BRCA	All	All	+1.393	<.001	4	view →
KIRP	All	III,IV	+1.339	.014	3	view →
ESCA	All	All	+2.544	.009	2	view →
PRAD	All	All	−1.855	<.001	2	view →
READ	All	All	−2.031	.032	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

CXCL13–HNSC

Open the HNSC breakdown →