CXCL13

Across TCGA cell cohorts, CXCL13 RNA expression is significantly associated with the go_rna of many other GO terms, with 738 significant associations in total. SOFT_TISSUE shows the largest number of these associations.

The most reproducible CXCL13-associated GO terms across cancer lineages are Positive regulation of toll-like receptor signaling pathway, Cholesterol biosynthetic process via desmosterol, and Cholesterol biosynthetic process via lathosterol. Each is linked with CXCL13 in more than 3 cancer types. Because this analysis shows association rather than direction, both CXCL13-to-partner and partner-to-CXCL13 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of toll-like receptor signaling pathway grouped by CXCL13-low versus CXCL13-high in PANCREAS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (CXCL13→partner) and Y-score (partner→CXCL13) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	Positive regulation of toll-like receptor signaling pathway →	+0.157	+0.029	<.001	.003	3	4
SOFT_TISSUE	Cholesterol biosynthetic process via desmosterol →	+0.151	+0.168	<.001	.001	3	4
SOFT_TISSUE	Cholesterol biosynthetic process via lathosterol →	+0.146	+0.110	<.001	.006	3	4
OESOPHAGUS	Sulfur compound biosynthetic process →	+0.083	+0.249	<.001	.006	3	3
PANCREAS	Ascorbate homeostasis →	-0.150	-0.039	.002	.005	3	3
SOFT_TISSUE	Negative regulation of potassium ion transmembrane transporter activity →	+0.775	+0.088	.002	.006	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 738 associations by consensus.

Positive regulation of toll-like receptor signaling pathway by CXCL13 expression — PANCREAS

Explore this box plot interactively →