CWC25

Across TCGA patient cohorts, CWC25 mutation is significantly associated with the RNA expression of many other genes, with 604 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CWC25-associated genes across cancer lineages are RNU6-158P, KRTAP1-3, and RNU6-1274P. Each is linked with CWC25 in more than 2 cancer types. Because this analysis shows association rather than direction, both CWC25-to-partner and partner-to-CWC25 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-158P grouped by CWC25-low versus CWC25-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CWC25→partner) and Y-score (partner→CWC25) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	RNU6-158P →	+0.296	+4.537	<.001	.006	3	3
CESC	KRTAP1-3 →	+0.641	+3.064	<.001	.007	3	2
COAD	RNU6-1274P →	+0.360	+4.537	<.001	.006	3	2
HNSC	PCMTD1P2 →	+0.118	+5.303	.001	.006	3	2
HNSC	RNU1-6P →	+0.672	+5.578	<.001	.004	3	2
CESC	RNU6-362P →	+0.393	+5.263	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 604 associations by consensus.

RNU6-158P by CWC25 expression — COAD

Explore this box plot interactively →