CUL4B

Across TCGA patient cohorts, CUL4B mutation is significantly associated with the RNA expression of many other genes, with 3,697 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CUL4B-associated genes across cancer lineages are SSXP9, CDRT15P7, and RN7SL248P. Each is linked with CUL4B in more than 2 cancer types. Because this analysis shows association rather than direction, both CUL4B-to-partner and partner-to-CUL4B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SSXP9 grouped by CUL4B-low versus CUL4B-high in STAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CUL4B→partner) and Y-score (partner→CUL4B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	SSXP9 →	+0.265	+4.219	.007	.009	3	3
LIHC	CDRT15P7 →	+0.082	+5.544	<.001	.004	3	3
HNSC	RN7SL248P →	+0.056	+4.763	<.001	.004	3	3
UCEC	LEO1 →	+0.345	+2.354	.001	<.001	3	3
BRCA	P3R3URF-PIK3R3 →	+0.070	+4.575	<.001	.009	3	2
UCEC	C17orf98 →	+0.227	+1.543	.006	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,697 associations by consensus.

SSXP9 by CUL4B expression — STAD

Explore this box plot interactively →