CUL4B

Across TCGA pan-cancer cohorts, CUL4B RNA is linked to patient survival in 27 of 34 cancer types, making it the most broadly survival-associated CUL4B data layer compared with 7 for mutation status and 6 for mass-spec protein.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher CUL4B RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated CUL4B expression acts as an unfavorable survival marker, although some lineages such as KIRC and ACC show a favorable association.

KIRC, KIRP, and MESO are the cancer types where CUL4B RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	DFS	Quartile	All	0.882	0.681	.001	71	view →
KIRP	DFS	Quartile	All	0.874	0.990	<.001	51	view →
MESO	OS	Quartile	All	0.364	0.715	.004	45	view →
LIHC	OS	Quartile	All	0.669	0.869	<.001	36	view →
ACC	DFS	Tertile	III,IV	0.551	0.088	.008	28	view →
LGG	OS	Median	All	0.319	0.576	<.001	27	view →
KICH	DFS	Quartile	II,III,IV	0.435	0.928	.008	25	view →
LUAD	OS	Tertile	All	0.741	0.850	.002	23	view →
BLCA	DFS	Quartile	All	0.239	0.670	<.001	18	view →
DLBC	DFS	Quartile	All	0.389	0.787	.017	17	view →
SCLC	DFS	Quartile	II,III,IV	0.680	0.285	.022	15	view →
UCEC	DFS	Quartile	All	0.567	0.696	.009	14	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 27 lineages.

CUL4B–KIRC (DFS)

Open the KIRC breakdown →