CUL4B

Across TCGA cell cohorts, CUL4B mutation is significantly associated with the RNA expression of many other genes, with 13 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CUL4B-associated genes across cancer lineages are CENPVL1, USP17L20, and USP17L18. Each is linked with CUL4B in more than 1 cancer types. Because this analysis shows association rather than direction, both CUL4B-to-partner and partner-to-CUL4B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CENPVL1 grouped by CUL4B-low versus CUL4B-high in OESOPHAGUS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CUL4B→partner) and Y-score (partner→CUL4B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	CENPVL1 →	+0.246	+4.906	<.001	.006	3	1
OESOPHAGUS	USP17L20 →	+0.050	+4.906	<.001	.006	3	1
OESOPHAGUS	USP17L18 →	+0.050	+4.906	<.001	.006	3	1
LUNG_NSCLC_LUAD	COX4I2 →	+0.095	+5.228	<.001	.005	3	1
LARGE_INTESTINE	VAX1 →	+0.627	+3.519	.001	.007	3	1
LARGE_INTESTINE	MMP26 →	+0.033	+3.217	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 13 associations by consensus.

CENPVL1 by CUL4B expression — OESOPHAGUS

Explore this box plot interactively →