CUL1

Across TCGA patient cohorts, CUL1 mutation is significantly associated with the RNA expression of many other genes, with 1,322 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CUL1-associated genes across cancer lineages are CCL4, SENP3-EIF4A1, and BRI3BP. Each is linked with CUL1 in more than 2 cancer types. Because this analysis shows association rather than direction, both CUL1-to-partner and partner-to-CUL1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CCL4 grouped by CUL1-low versus CUL1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CUL1→partner) and Y-score (partner→CUL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	CCL4 →	+0.654	+1.914	.002	<.001	3	3
UCEC	SENP3-EIF4A1 →	+0.111	+2.004	<.001	<.001	3	3
UCEC	BRI3BP →	+0.493	+2.180	.001	<.001	3	3
UCEC	LONP1 →	+0.548	+2.279	<.001	<.001	3	3
UCEC	IL21R →	+0.409	+2.287	.002	<.001	3	3
UCEC	VPS18 →	+0.429	+1.643	<.001	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,322 associations by consensus.

CCL4 by CUL1 expression — UCEC

Explore this box plot interactively →