CUL1

Across TCGA pan-cancer cohorts, CUL1 RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of CUL1’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where CUL1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types CUL1 is over-expressed in tumor, although a few such as THCA and PRAD show the opposite, repressed pattern.

HNSC, KIRC, and LIHC are the cancer types where CUL1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in CUL1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	III,IV	+0.578	<.001	12	view →
KIRC	All	IV	+0.580	<.001	11	view →
LIHC	Male	All	+0.730	<.001	9	view →
COAD	Female	II,III,IV	+0.677	<.001	9	view →
KIRP	All	II,III,IV	+0.516	.001	8	view →
LUSC	Male	II,III,IV	+0.509	<.001	6	view →
READ	All	III,IV	+0.595	.006	5	view →
LUAD	All	IV	+0.439	.006	3	view →
CHOL	All	All	+0.884	<.001	2	view →
ESCA	All	All	+0.821	<.001	2	view →
THCA	All	IV	−0.225	.018	2	view →
PRAD	All	All	−0.220	.024	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

CUL1–HNSC

Open the HNSC breakdown →