CTU1

Across TCGA cell cohorts, CTU1 mutation is significantly associated with the RNA expression of many other genes, with 14 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CTU1-associated genes across cancer lineages are SH3GL2, GHR, and SLCO1C1. Each is linked with CTU1 in more than 1 cancer types. Because this analysis shows association rather than direction, both CTU1-to-partner and partner-to-CTU1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SH3GL2 grouped by CTU1-low versus CTU1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CTU1→partner) and Y-score (partner→CTU1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	SH3GL2 →	+1.094	+3.252	.006	.009	3	1
LARGE_INTESTINE	GHR →	+0.554	+3.295	<.001	.009	3	1
LARGE_INTESTINE	SLCO1C1 →	+0.366	+3.772	.001	.003	3	1
LARGE_INTESTINE	TKTL2 →	+0.038	+3.187	.001	.006	3	1
LARGE_INTESTINE	OR2V2 →	+0.014	+3.247	<.001	.001	3	1
LARGE_INTESTINE	DBX2 →	+0.009	+3.240	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 14 associations by consensus.

SH3GL2 by CTU1 expression — LARGE_INTESTINE

Explore this box plot interactively →