CTSZ

Across TCGA patient cohorts, CTSZ protein abundance is significantly associated with the RNA expression of many other genes, with 17,791 significant associations in total. GBM shows the largest number of these associations.

The most reproducible CTSZ-associated genes across cancer lineages are SLCO2B1, ITGB2, and HTRA4. Each is linked with CTSZ in more than 7 cancer types. Because this analysis shows association rather than direction, both CTSZ-to-partner and partner-to-CTSZ results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, CTSZ versus SLCO2B1 in LSCC, with a Pearson correlation of 0.69.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CTSZ→partner) and Y-score (partner→CTSZ) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	SLCO2B1 →	+0.891	+0.363	<.001	<.001	3	8
GBM	ITGB2 →	+1.078	+0.668	<.001	<.001	3	8
CCRCC	HTRA4 →	+1.057	+0.447	<.001	<.001	3	8
GBM	IL10RA →	+1.086	+0.647	<.001	<.001	3	8
HNSC	SNX20 →	+0.807	+0.375	<.001	<.001	3	8
CCRCC	LILRB5 →	+0.889	+0.408	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 17,791 associations by consensus.

CTSZ vs SLCO2B1 — LSCC

Explore this scatter interactively →