CTSZ

Across TCGA pan-cancer cohorts, CTSZ RNA differs between tumor and matched normal tissue in 9 of 18 cancer types tested, making tumor–normal expression one of CTSZ’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where CTSZ RNA is more highly expressed in tumor relative to normal tissue. In most cancer types CTSZ is over-expressed in tumor, although a few such as LUSC and THCA show the opposite, repressed pattern.

KIRC, HNSC, and STAD are the cancer types where CTSZ tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in CTSZ RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Female	IV	+1.873	<.001	12	view →
HNSC	All	III,IV	+1.375	<.001	12	view →
STAD	All	II,III,IV	+1.441	<.001	10	view →
LUSC	Male	All	−0.663	<.001	6	view →
ESCA	All	All	+1.514	.008	4	view →
KIRP	Male	All	+1.025	<.001	4	view →
THCA	Male	II,III,IV	−0.371	.003	3	view →
UCEC	All	All	+0.400	.047	2	view →
COAD	Female	II,III,IV	−0.372	.023	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 9 strongest of 9 lineages.

CTSZ–KIRC

Open the KIRC breakdown →