CTSZ

Across TCGA cell cohorts, CTSZ mutation is significantly associated with the RNA expression of many other genes, with 11 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible CTSZ-associated genes across cancer lineages are TBC1D3, LRRC74A, and BTBD16. Each is linked with CTSZ in more than 1 cancer types. Because this analysis shows association rather than direction, both CTSZ-to-partner and partner-to-CTSZ results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TBC1D3 grouped by CTSZ-low versus CTSZ-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CTSZ→partner) and Y-score (partner→CTSZ) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	TBC1D3 →	+0.080	+4.273	<.001	.006	3	1
BLOOD_Leukemia	LRRC74A →	+0.020	+3.551	.007	.009	3	1
BLOOD_Leukemia	BTBD16 →	+0.134	+3.959	<.001	.005	3	1
BLOOD_Leukemia	VWC2L →	+0.012	+4.339	<.001	.002	3	1
BLOOD_Leukemia	FAM216B →	+0.146	+3.944	<.001	.006	3	1
BLOOD_Leukemia	RXFP3 →	+0.010	+3.874	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 11 associations by consensus.

TBC1D3 by CTSZ expression — LARGE_INTESTINE

Explore this box plot interactively →