CTSB

Across TCGA patient cohorts, CTSB protein abundance is significantly associated with the RNA expression of many other genes, with 16,172 significant associations in total. GBM shows the largest number of these associations.

The most reproducible CTSB-associated genes across cancer lineages are FAM20A, SPOCD1, and VSIG4. Each is linked with CTSB in more than 6 cancer types. Because this analysis shows association rather than direction, both CTSB-to-partner and partner-to-CTSB results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, CTSB versus FAM20A in LSCC, with a Pearson correlation of 0.50.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CTSB→partner) and Y-score (partner→CTSB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	FAM20A →	+0.697	+0.392	<.001	<.001	3	7
GBM	SPOCD1 →	+1.454	+0.482	<.001	<.001	3	7
GBM	VSIG4 →	+1.378	+0.659	<.001	<.001	3	7
GBM	FCER1G →	+1.095	+0.667	<.001	<.001	3	7
GBM	PELATON →	+0.787	+0.589	<.001	<.001	3	7
GBM	FCGR2B →	+1.403	+0.625	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 16,172 associations by consensus.

CTSB vs FAM20A — LSCC

Explore this scatter interactively →