CTSB

Across TCGA pan-cancer cohorts, CTSB RNA is linked to patient survival in 28 of 34 cancer types, making it the most broadly survival-associated CTSB data layer compared with 6 for mutation status and 8 for mass-spec protein.

The strongest signal is observed in mesothelioma (MESO), where higher CTSB RNA is associated with worse overall survival. In most high-consensus cancer types, elevated CTSB expression acts as an unfavorable survival marker, although some lineages such as THCA and UCEC show a favorable association.

MESO, BLCA, and KICH are the cancer types where CTSB RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
MESO	OS	Median	All	0.192	0.369	.003	77	view →
BLCA	DFS	Median	II,III,IV	0.455	0.560	.005	60	view →
KICH	DFS	Quartile	II,III,IV	0.522	1.000	.002	49	view →
LGG	DFS	Median	All	0.664	0.809	<.001	46	view →
GBM	DFS	Quartile	All	0.187	0.408	<.001	38	view →
THCA	OS	Tertile	II,III,IV	1.000	0.942	.005	37	view →
UCEC	DFS	Median	All	0.744	0.546	.002	30	view →
DLBC	DFS	Quartile	All	1.000	0.377	.018	19	view →
LAML	DFS	Median	All	0.292	0.477	.014	18	view →
LIHC	OS	Tertile	All	0.298	0.694	.001	18	view →
ESCA	DFS	Tertile	All	1.000	0.372	.007	15	view →
UVM	OS	Tertile	All	0.329	0.658	.005	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 28 lineages.

CTSB–MESO (OS)

Open the MESO breakdown →