CTRL

Across TCGA patient cohorts, CTRL mutation is significantly associated with the RNA expression of many other genes, with 1,231 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CTRL-associated genes across cancer lineages are MIR4769, RNA5SP416, and MIR6803. Each is linked with CTRL in more than 1 cancer types. Because this analysis shows association rather than direction, both CTRL-to-partner and partner-to-CTRL results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR4769 grouped by CTRL-low versus CTRL-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CTRL→partner) and Y-score (partner→CTRL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MIR4769 →	+0.266	+3.027	<.001	.007	3	2
UCEC	RNA5SP416 →	+0.612	+2.639	<.001	.001	3	2
UCEC	MIR6803 →	+0.183	+4.777	<.001	.002	3	1
UCEC	BACE1-AS →	+0.437	+2.711	.006	.003	3	1
LUAD	RNU6-730P →	+0.407	+5.554	<.001	.004	3	1
LUAD	MIR572 →	+0.433	+5.343	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,231 associations by consensus.

MIR4769 by CTRL expression — UCEC

Explore this box plot interactively →