CTRL

Across TCGA pan-cancer cohorts, CTRL RNA is linked to patient survival in 23 of 34 cancer types, making it the most broadly survival-associated CTRL data layer compared with 5 for mutation status and 1 for mass-spec protein.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher CTRL RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated CTRL expression acts as an unfavorable survival marker, although some lineages such as BLCA and HNSC show a favorable association.

KIRC, BLCA, and HNSC are the cancer types where CTRL RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	DFS	Median	All	0.516	0.707	<.001	109	view →
BLCA	OS	Median	IV	0.703	0.494	.005	58	view →
HNSC	OS	Tertile	II,III,IV	0.780	0.623	.004	48	view →
BRCA	OS	Median	All	0.649	0.512	.002	35	view →
SKCM	OS	Median	III,IV	0.795	0.627	.001	35	view →
CESC	OS	Quartile	All	0.897	0.720	.004	32	view →
LUSC	DFS	Median	IV	0.134	0.827	.014	32	view →
ACC	OS	Quartile	II,III,IV	0.510	0.876	.005	24	view →
PRAD	DFS	Tertile	All	0.844	0.934	.002	22	view →
CHOL	DFS	Quartile	All	0.705	0.108	<.001	19	view →
MESO	OS	Quartile	All	0.312	0.748	.008	18	view →
LGG	DFS	Tertile	All	0.787	0.891	.001	17	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

CTRL–KIRC (DFS)

Open the KIRC breakdown →