CTRL

Across TCGA pan-cancer cohorts, CTRL RNA differs between tumor and matched normal tissue in 7 of 18 cancer types tested, making tumor–normal expression one of CTRL’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where CTRL RNA is more highly expressed in tumor relative to normal tissue. In most cancer types CTRL is over-expressed in tumor, although a few such as THCA show the opposite, repressed pattern.

COAD, THCA, and STAD are the cancer types where CTRL tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in CTRL RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	All	All	+0.060	<.001	9	view →
THCA	All	All	−0.027	.008	4	view →
STAD	Male	II,III,IV	+0.068	.012	3	view →
KICH	Female	III,IV	+0.053	.007	3	view →
CHOL	All	All	+0.080	.015	2	view →
LIHC	Female	II,III,IV	+0.039	.019	2	view →
KIRC	Male	All	+0.024	.021	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 7 strongest of 7 lineages.

CTRL–COAD

Open the COAD breakdown →