CTRL

Across TCGA patient cohorts, CTRL mutation is significantly associated with the total protein of many other genes, with 10 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CTRL-associated genes across cancer lineages are 14-3-3_beta, A-Raf_pS299, and Ku80. Each is linked with CTRL in more than 1 cancer types. Because this analysis shows association rather than direction, both CTRL-to-partner and partner-to-CTRL results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 14-3-3_beta grouped by CTRL-low versus CTRL-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CTRL→partner) and Y-score (partner→CTRL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	14-3-3_beta →	-0.134	-3.149	.007	.019	3	1
UCEC	A-Raf_pS299 →	-0.136	-2.321	.023	.035	3	1
UCEC	Ku80 →	+0.305	+2.335	.010	.020	3	1
UCEC	p62 Lck ligand →	+0.581	+3.009	<.001	.019	3	1
UCEC	P-Cadherin →	-0.215	-3.446	.003	.005	3	1
UCEC	Caspase-8 →	-0.298	-3.459	.018	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 10 associations by consensus.

14-3-3_beta by CTRL expression — UCEC

Explore this box plot interactively →