CTPS1

Across TCGA patient cohorts, CTPS1 mutation is significantly associated with the RNA expression of many other genes, with 1,669 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CTPS1-associated genes across cancer lineages are NFYBP1, CYCSP49, and BTF3P15. Each is linked with CTPS1 in more than 1 cancer types. Because this analysis shows association rather than direction, both CTPS1-to-partner and partner-to-CTPS1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NFYBP1 grouped by CTPS1-low versus CTPS1-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CTPS1→partner) and Y-score (partner→CTPS1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	NFYBP1 →	+0.260	+3.897	.004	.004	3	2
COAD	CYCSP49 →	+0.160	+5.142	<.001	.002	3	2
COAD	BTF3P15 →	+0.209	+4.516	<.001	.001	3	2
COAD	IGKV1OR2-9 →	+0.714	+3.597	.008	.009	3	2
SKCM	FAM138D →	+0.020	+4.385	<.001	.008	3	2
BLCA	OR2U1P →	+0.103	+5.685	<.001	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,669 associations by consensus.

NFYBP1 by CTPS1 expression — COAD

Explore this box plot interactively →