CTNND2

Across TCGA cell cohorts, CTNND2 mutation is significantly associated with the RNA expression of many other genes, with 270 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible CTNND2-associated genes across cancer lineages are TBC1D3H, USP29, and LEUTX. Each is linked with CTNND2 in more than 1 cancer types. Because this analysis shows association rather than direction, both CTNND2-to-partner and partner-to-CTNND2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TBC1D3H grouped by CTNND2-low versus CTNND2-high in PANCREAS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CTNND2→partner) and Y-score (partner→CTNND2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	TBC1D3H →	+1.533	+4.011	<.001	.009	3	2
URINARY_TRACT	USP29 →	+0.025	+4.087	<.001	.009	3	2
CNS	LEUTX →	+0.226	+5.321	<.001	.005	3	2
SOFT_TISSUE	PPIAL4F →	+0.053	+3.930	<.001	.001	3	2
OESOPHAGUS	KHDC3L →	+0.037	+2.432	.004	.008	3	2
LUNG_SCLC	HDAC5 →	-0.973	-3.169	<.001	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 270 associations by consensus.

TBC1D3H by CTNND2 expression — PANCREAS

Explore this box plot interactively →