CTNND2

Across TCGA pan-cancer cohorts, CTNND2 RNA is linked to patient survival in 21 of 34 cancer types, making it the most broadly survival-associated CTNND2 data layer compared with 11 for mutation status and 3 for mass-spec protein.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where higher CTNND2 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated CTNND2 expression acts as an unfavorable survival marker, although some lineages such as LUAD and HNSC show a favorable association.

KIRP, UVM, and LUAD are the cancer types where CTNND2 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRP	DFS	Tertile	All	0.753	0.945	<.001	109	view →
UVM	OS	Tertile	All	0.420	0.846	<.001	97	view →
LUAD	OS	Tertile	All	0.576	0.293	.003	54	view →
ESCA	DFS	Median	IV	0.205	0.634	.006	30	view →
HNSC	DFS	Quartile	IV	0.534	0.290	.003	28	view →
SKCM	DFS	Tertile	IV	0.041	0.450	.004	28	view →
MESO	DFS	Tertile	III,IV	0.291	0.520	.016	17	view →
CHOL	DFS	Median	III,IV	0.127	0.647	.006	17	view →
STAD	DFS	Tertile	All	0.458	0.677	.020	14	view →
ACC	DFS	Median	IV	0.453	0.108	.019	13	view →
CESC	DFS	Tertile	IV	0.745	0.289	.017	12	view →
PAAD	DFS	Quartile	All	0.637	0.345	.005	8	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 21 lineages.

CTNND2–KIRP (DFS)

Open the KIRP breakdown →