Across TCGA patient cohorts, CTNNA3 mutation is significantly associated with the RNA expression of many other genes, with 4,666 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CTNNA3-associated genes across cancer lineages are ITPK1, PSMD9, and HROB. Each is linked with CTNNA3 in more than 3 cancer types. Because this analysis shows association rather than direction, both CTNNA3-to-partner and partner-to-CTNNA3 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CTNNA3→partner) and Y-score (partner→CTNNA3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ITPK1 →	+0.278	+1.684	.007	.003	3	4
UCEC	PSMD9 →	+0.320	+1.539	<.001	.004	3	4
UCEC	HROB →	+0.529	+1.895	<.001	<.001	3	4
SKCM	RITA1 →	+0.269	+1.201	<.001	.002	3	4
SKCM	BTBD6 →	+0.284	+1.832	.004	.001	3	4
UCEC	CNTROB →	+0.343	+1.505	<.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,666 associations by consensus.

Exploration

CTNNA3 survival (RNA) · tumor vs normal (RNA) · all CTNNA3 data types