Across TCGA pan-cancer cohorts, CTNNA3 RNA differs between tumor and matched normal tissue in 15 of 18 cancer types tested, making tumor–normal expression one of CTNNA3’s most consistent transcriptional readouts.
The strongest signal is observed in colon adenocarcinoma (COAD), where CTNNA3 RNA is repressed in tumor relative to normal tissue. In most cancer types CTNNA3 is over-expressed in tumor, although a few such as COAD and THCA show the opposite, repressed pattern.
COAD, THCA, and BLCA are the cancer types where CTNNA3 tumor–normal differential expression is most reproducible.
RNA tumor vs normal associations by lineage
Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in CTNNA3 RNA (log2); positive values indicate higher expression in tumor. p-values are from the differential-expression test.