CTBP1

Across TCGA cell cohorts, CTBP1 mutation is significantly associated with the RNA expression of many other genes, with 50 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CTBP1-associated genes across cancer lineages are LYPD2, ONECUT1, and GPR148. Each is linked with CTBP1 in more than 1 cancer types. Because this analysis shows association rather than direction, both CTBP1-to-partner and partner-to-CTBP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LYPD2 grouped by CTBP1-low versus CTBP1-high in CNS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CTBP1→partner) and Y-score (partner→CTBP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	LYPD2 →	+1.077	+4.169	.007	.008	3	2
OVARY	ONECUT1 →	+0.820	+3.362	<.001	.005	3	1
OVARY	GPR148 →	+0.038	+2.832	<.001	.004	3	1
OVARY	TMEM89 →	+0.099	+3.378	<.001	.006	3	1
OVARY	KRTAP5-6 →	+0.087	+3.022	.007	.005	3	1
OVARY	PAPOLB →	+0.009	+3.376	.002	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 50 associations by consensus.

LYPD2 by CTBP1 expression — CNS

Explore this box plot interactively →