CTBP1

Across TCGA pan-cancer cohorts, CTBP1 RNA is linked to patient survival in 21 of 34 cancer types, making it the most broadly survival-associated CTBP1 data layer compared with 6 for mutation status and 7 for mass-spec protein.

The strongest signal is observed in uveal melanoma (UVM), where higher CTBP1 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated CTBP1 expression acts as an unfavorable survival marker, although some lineages such as UCEC and SKCM show a favorable association.

UVM, UCEC, and LUSC are the cancer types where CTBP1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	DFS	Quartile	III,IV	0.351	0.918	.002	65	view →
UCEC	DFS	Quartile	III,IV	0.812	0.607	.009	44	view →
LUSC	DFS	Median	II,III,IV	0.507	0.705	<.001	43	view →
SARC	OS	Median	All	0.447	0.727	<.001	35	view →
LIHC	OS	Median	II,III,IV	0.511	0.707	.009	29	view →
ACC	DFS	Tertile	All	0.294	0.794	.009	28	view →
SKCM	DFS	Tertile	All	0.815	0.652	.001	27	view →
PAAD	OS	Quartile	All	0.571	0.208	.001	24	view →
KIRC	DFS	Quartile	II,III,IV	0.721	0.840	.011	22	view →
KICH	OS	Tertile	III,IV	0.159	0.913	.004	18	view →
LGG	DFS	Tertile	All	0.609	0.819	<.001	17	view →
UCS	DFS	Median	III,IV	0.457	0.136	.022	16	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 21 lineages.

CTBP1–UVM (DFS)

Open the UVM breakdown →