CSTF3-DT

Across TCGA patient cohorts, CSTF3-DT mutation is significantly associated with the RNA expression of many other genes, with 3 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CSTF3-DT-associated genes across cancer lineages are FAM197Y1, TAF9P1, and RN7SKP135. Each is linked with CSTF3-DT in more than 1 cancer types. Because this analysis shows association rather than direction, both CSTF3-DT-to-partner and partner-to-CSTF3-DT results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FAM197Y1 grouped by CSTF3-DT-low versus CSTF3-DT-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CSTF3-DT→partner) and Y-score (partner→CSTF3-DT) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FAM197Y1 →	+0.049	+8.066	<.001	.007	3	1
UCEC	TAF9P1 →	+0.069	+8.066	<.001	.007	3	1
UCEC	RN7SKP135 →	+0.173	+8.066	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 3 strongest of 3 associations by consensus.

FAM197Y1 by CSTF3-DT expression — UCEC

Explore this box plot interactively →