CSTF3-DT

Across TCGA pan-cancer cohorts, CSTF3-DT RNA differs between tumor and matched normal tissue in 10 of 18 cancer types tested, making tumor–normal expression one of CSTF3-DT’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where CSTF3-DT RNA is more highly expressed in tumor relative to normal tissue. In most cancer types CSTF3-DT is over-expressed in tumor, although a few such as KICH show the opposite, repressed pattern.

KIRP, KICH, and HNSC are the cancer types where CSTF3-DT tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in CSTF3-DT RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRP	All	II,III,IV	+0.105	<.001	10	view →
KICH	Female	All	−0.080	<.001	7	view →
HNSC	All	All	+0.065	<.001	7	view →
BRCA	All	II,III,IV	+0.104	<.001	6	view →
LUAD	All	All	+0.121	<.001	5	view →
LUSC	Male	II,III,IV	+0.198	<.001	4	view →
STAD	All	II,III,IV	+0.090	.019	2	view →
LIHC	All	All	+0.049	<.001	2	view →
KIRC	All	All	+0.033	.001	2	view →
ESCA	Female	All	+0.153	.001	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 10 strongest of 10 lineages.

CSTF3-DT–KIRP

Open the KIRP breakdown →