CSTF3-DT

Across TCGA pan-cancer cohorts, CSTF3-DT RNA is linked to patient survival in 22 of 34 cancer types, making it the most broadly survival-associated CSTF3-DT data layer.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher CSTF3-DT RNA is associated with worse overall survival. In most high-consensus cancer types, elevated CSTF3-DT expression acts as an unfavorable survival marker, although some lineages such as BRCA and SKCM show a favorable association.

KIRC, ACC, and BRCA are the cancer types where CSTF3-DT RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	OS	Median	II,III,IV	0.443	0.605	.001	107	view →
ACC	DFS	Median	All	0.276	0.581	.001	74	view →
BRCA	DFS	Median	III,IV	0.924	0.826	.001	58	view →
MESO	DFS	Median	II,III,IV	0.299	0.602	.014	27	view →
SKCM	OS	Median	III,IV	0.539	0.285	.006	23	view →
LIHC	OS	Median	II,III,IV	0.511	0.680	.006	22	view →
THYM	OS	Median	All	1.000	0.606	<.001	16	view →
COAD	DFS	Quartile	II,III,IV	0.400	0.575	.013	15	view →
UCS	DFS	Tertile	IV	0.996	0.540	.036	14	view →
STAD	DFS	Quartile	II,III,IV	0.709	0.494	.006	13	view →
HNSC	OS	Median	III,IV	0.453	0.262	.018	13	view →
KIRP	OS	Median	II,III,IV	0.495	0.876	.016	11	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

CSTF3-DT–KIRC (OS)

Open the KIRC breakdown →