CST5

Across TCGA patient cohorts, CST5 mutation is significantly associated with the RNA expression of many other genes, with 181 significant associations in total. LUSC shows the largest number of these associations.

The most reproducible CST5-associated genes across cancer lineages are SUGT1P4, MIR941-5, and OR4C11. Each is linked with CST5 in more than 2 cancer types. Because this analysis shows association rather than direction, both CST5-to-partner and partner-to-CST5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SUGT1P4 grouped by CST5-low versus CST5-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CST5→partner) and Y-score (partner→CST5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	SUGT1P4 →	+0.167	+4.257	<.001	.007	3	3
LUAD	MIR941-5 →	+0.652	+5.044	<.001	.009	3	2
BLCA	OR4C11 →	+0.034	+7.640	<.001	.009	3	2
LUSC	RPL21P71 →	+0.322	+3.687	<.001	.007	3	2
LUSC	RN7SL266P →	+0.078	+4.116	<.001	.009	3	2
LUSC	GMFBP1 →	+0.127	+3.876	.006	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 181 associations by consensus.

SUGT1P4 by CST5 expression — LUSC

Explore this box plot interactively →