CST5

Across TCGA pan-cancer cohorts, CST5 RNA is linked to patient survival in 22 of 34 cancer types, making it the most broadly survival-associated CST5 data layer compared with 2 for mutation status.

The strongest signal is observed in uveal melanoma (UVM), where higher CST5 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated CST5 expression acts as an unfavorable survival marker, although some lineages such as MESO and CHOL show a favorable association.

UVM, DLBC, and KIRP are the cancer types where CST5 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	DFS	Tertile	All	0.508	0.802	.002	78	view →
DLBC	DFS	Tertile	II,III,IV	0.338	0.825	.004	76	view →
KIRP	OS	Tertile	III,IV	0.503	0.946	<.001	47	view →
MESO	DFS	Tertile	II,III,IV	0.499	0.299	.006	36	view →
CHOL	DFS	Tertile	II,III,IV	0.722	0.093	.003	36	view →
ACC	DFS	Quartile	II,III,IV	0.411	0.772	.002	36	view →
STAD	OS	Quartile	III,IV	0.306	0.538	.009	34	view →
KIRC	DFS	Tertile	All	0.498	0.691	.002	28	view →
LGG	DFS	Tertile	All	0.844	0.707	.005	26	view →
LUAD	DFS	Quartile	All	0.843	0.722	.002	19	view →
THCA	DFS	Quartile	All	0.805	0.508	.007	14	view →
PAAD	OS	Tertile	All	0.309	0.546	.015	14	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

CST5–UVM (DFS)

Open the UVM breakdown →