Q-omics provides the consensus-scored CSP1 profile across patient tissues and cancer cell-line models. CSP1 expression is associated with patient survival in 15 of 34 cancer types, with the highest sampling consensus in UVM. Among the 18 cancer types available for tumor–normal comparison, CSP1 is differentially expressed in 4, with the highest sampling consensus in BRCA. Additionally, CSP1 RNA expression shows 10,894 significant gene co-expression associations, with the highest sampling consensus in TGCT. Together, these results highlight UVM, BRCA, and TGCT as cancer lineages where CSP1 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for CSP1 — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes CSP1 survival associations across molecular data types. CSP1 RNA expression shows survival associations in the most cancer types (15). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible CSP1 RNA expression–survival associations across cancer types. High CSP1 expression shows unfavorable associations in UVM, MESO, KICH, LGG and PCPG, but favorable associations in UCS. The UVM Kaplan–Meier curve shows clear separation, with the high-expression group declining faster, consistent with the unfavorable association (log-rank p < 0.001). Together, the overview and detailed table identify UVM as the clearest survival context for CSP1 RNA expression.
This table summarizes CSP1 tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 4. The strongest signals are observed in BRCA for RNA.
This table ranks reproducible tumor–normal expression differences for CSP1. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. CSP1 shows lower tumor expression in BRCA and higher tumor expression in UCEC, COAD and LUSC. The BRCA box plot shows higher CSP1 RNA expression in normal versus tumor tissue (log2 FC = −0.385, t-test p = .001).
This table shows molecular features associated with CSP1 in patient tissues and cancer cell lines. In patient samples, CSP1 shows the broadest associations at the RNA and protein expression levels, with TGCT recurring as the lineage with the largest associated feature set.
