CSMD3

Across TCGA patient cohorts, CSMD3 mutation is significantly associated with the total protein of many other genes, with 119 significant associations in total. LUAD shows the largest number of these associations.

The most reproducible CSMD3-associated genes across cancer lineages are Cyclin-E2, Akt, and ATM. Each is linked with CSMD3 in more than 6 cancer types. Because this analysis shows association rather than direction, both CSMD3-to-partner and partner-to-CSMD3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cyclin-E2 grouped by CSMD3-low versus CSMD3-high in READ.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CSMD3→partner) and Y-score (partner→CSMD3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
READ	Cyclin-E2 →	+0.185	+3.000	.009	.032	3	7
LUAD	Akt →	-0.202	-1.087	.004	.004	3	6
LUAD	ATM →	-0.220	-0.921	.012	.008	3	6
READ	Chk1 →	+0.260	+3.000	.023	.032	3	6
LUAD	4E-BP1_pT70 →	+0.110	+0.817	.002	.015	3	6
COAD	Caspase-7-cleavedD198 →	+0.890	+2.395	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 119 associations by consensus.

Cyclin-E2 by CSMD3 expression — READ

Explore this box plot interactively →