CSMD3

Across TCGA pan-cancer cohorts, CSMD3 RNA is linked to patient survival in 21 of 34 cancer types, making it the most broadly survival-associated CSMD3 data layer compared with 11 for mutation status and 1 for mass-spec protein.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher CSMD3 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated CSMD3 expression acts as an unfavorable survival marker, although some lineages such as LGG and PAAD show a favorable association.

KIRC, LUAD, and KIRP are the cancer types where CSMD3 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	DFS	Median	All	0.553	0.680	<.001	96	view →
LUAD	DFS	Median	All	0.718	0.856	<.001	67	view →
KIRP	DFS	Tertile	II,III,IV	0.127	0.713	.001	57	view →
LGG	DFS	Median	All	0.837	0.636	<.001	51	view →
THCA	OS	Median	IV	0.520	0.939	<.001	50	view →
LUSC	OS	Median	All	0.718	0.903	.001	47	view →
BLCA	DFS	Median	All	0.552	0.666	.006	45	view →
LIHC	OS	Tertile	All	0.353	0.666	<.001	36	view →
READ	DFS	Tertile	All	0.217	0.683	.005	27	view →
DLBC	OS	Tertile	II,III,IV	0.294	1.000	.007	22	view →
HNSC	OS	Quartile	IV	0.338	0.757	.001	18	view →
CHOL	OS	Tertile	III,IV	0.275	0.886	.045	18	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 21 lineages.

CSMD3–KIRC (DFS)

Open the KIRC breakdown →