CSMD3

Across TCGA pan-cancer cohorts, CSMD3 RNA differs between tumor and matched normal tissue in 10 of 18 cancer types tested, making tumor–normal expression one of CSMD3’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where CSMD3 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types CSMD3 is over-expressed in tumor, although a few such as KIRC and KIRP show the opposite, repressed pattern.

HNSC, BRCA, and KIRC are the cancer types where CSMD3 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in CSMD3 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	All	+0.116	<.001	11	view →
BRCA	All	II,III,IV	+0.216	.007	6	view →
KIRC	Male	All	−0.027	<.001	6	view →
KIRP	Male	All	−0.037	<.001	3	view →
COAD	Male	II,III,IV	−0.031	.006	3	view →
LIHC	All	All	+0.030	.013	2	view →
UCEC	All	III,IV	−0.028	.035	2	view →
KICH	Female	All	−0.049	.031	1	view →
STAD	All	III,IV	−0.025	.048	1	view →
LUAD	Female	II,III,IV	−0.020	.014	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 10 strongest of 10 lineages.

CSMD3–HNSC

Open the HNSC breakdown →