CSMD3

Across TCGA cell cohorts, CSMD3 mutation is significantly associated with the RNA expression of many other genes, with 1,771 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible CSMD3-associated genes across cancer lineages are LRRCC1, SRPRB, and CCNI. Each is linked with CSMD3 in more than 3 cancer types. Because this analysis shows association rather than direction, both CSMD3-to-partner and partner-to-CSMD3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LRRCC1 grouped by CSMD3-low versus CSMD3-high in LUNG_NSCLC_LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CSMD3→partner) and Y-score (partner→CSMD3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	LRRCC1 →	+0.933	+2.807	.001	.004	3	3
LUNG_NSCLC_LUSC	SRPRB →	+0.667	+1.222	.003	.001	3	3
BREAST	CCNI →	+0.651	+2.459	<.001	.005	3	3
BREAST	TTC21B →	+0.608	+2.152	.003	.005	3	3
OVARY	KLHL25 →	+0.681	+3.093	<.001	.005	3	3
LUNG_SCLC	CUZD1 →	+0.532	+1.485	.002	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,771 associations by consensus.

LRRCC1 by CSMD3 expression — LUNG_NSCLC_LUSC

Explore this box plot interactively →