CSMD2

Across TCGA patient cohorts, CSMD2 mutation is significantly associated with the RNA expression of many other genes, with 10,357 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CSMD2-associated genes across cancer lineages are CDCA4, CDCA8, and RCC1. Each is linked with CSMD2 in more than 6 cancer types. Because this analysis shows association rather than direction, both CSMD2-to-partner and partner-to-CSMD2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CDCA4 grouped by CSMD2-low versus CSMD2-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CSMD2→partner) and Y-score (partner→CSMD2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	CDCA4 →	+0.730	+1.898	<.001	<.001	3	7
LUAD	CDCA8 →	+1.008	+2.082	<.001	<.001	3	7
STAD	RCC1 →	+0.604	+2.050	<.001	<.001	3	7
LUAD	POC1A →	+0.624	+1.748	<.001	<.001	3	6
STAD	SAC3D1 →	+0.420	+1.492	.003	.007	3	6
LUAD	RCE1 →	+0.297	+1.464	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 10,357 associations by consensus.

CDCA4 by CSMD2 expression — LUAD

Explore this box plot interactively →