Across TCGA patient cohorts, CSHL1 mutation is significantly associated with the RNA expression of many other genes, with 3,657 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CSHL1-associated genes across cancer lineages are LRR1, RNU6-23P, and RNA5SP172. Each is linked with CSHL1 in more than 2 cancer types. Because this analysis shows association rather than direction, both CSHL1-to-partner and partner-to-CSHL1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CSHL1→partner) and Y-score (partner→CSHL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	LRR1 →	+0.626	+3.021	<.001	<.001	3	3
HNSC	RNU6-23P →	+0.196	+3.548	.001	.005	3	3
HNSC	RNA5SP172 →	+0.190	+3.600	.001	.005	3	3
HNSC	RPSAP35 →	+0.055	+4.718	<.001	<.001	3	3
BLCA	RNU6-1133P →	+0.462	+5.788	<.001	.003	3	3
SKCM	RNU6-921P →	+0.139	+2.389	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,657 associations by consensus.

Exploration

CSHL1 survival (RNA) · tumor vs normal (RNA) · all CSHL1 data types