Across TCGA pan-cancer cohorts, CSHL1 RNA differs between tumor and matched normal tissue in 1 of 18 cancer types tested, making tumor–normal expression one of CSHL1’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where CSHL1 RNA is repressed in tumor relative to normal tissue. In most cancer types CSHL1 is over-expressed in tumor, although a few such as THCA show the opposite, repressed pattern.

THCA are the cancer types where CSHL1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in CSHL1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	Female	All	−0.014	.029	3	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 1 strongest of 1 lineages.

Exploration

Same gene, other analysis: CSHL1 RNA expression & survival · all CSHL1 data types