CSF3R

Across TCGA cell cohorts, CSF3R mutation is significantly associated with the RNA expression of many other genes, with 48 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CSF3R-associated genes across cancer lineages are SLC4A1, ANKRD30BL, and OLIG3. Each is linked with CSF3R in more than 1 cancer types. Because this analysis shows association rather than direction, both CSF3R-to-partner and partner-to-CSF3R results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SLC4A1 grouped by CSF3R-low versus CSF3R-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CSF3R→partner) and Y-score (partner→CSF3R) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	SLC4A1 →	+0.032	+3.144	.001	.001	3	2
PANCREAS	ANKRD30BL →	+0.016	+5.000	<.001	.006	3	1
PANCREAS	OLIG3 →	+0.006	+5.000	<.001	.006	3	1
BLOOD_Leukemia	RHCG →	+0.085	+3.729	.001	.009	3	1
BLOOD_Leukemia	TACR3 →	+0.019	+3.475	<.001	.006	3	1
BLOOD_Leukemia	SPACA5 →	+0.108	+3.745	.006	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 48 associations by consensus.

SLC4A1 by CSF3R expression — LARGE_INTESTINE

Explore this box plot interactively →