CSF3R

Across TCGA pan-cancer cohorts, CSF3R RNA is linked to patient survival in 24 of 34 cancer types, making it the most broadly survival-associated CSF3R data layer compared with 5 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher CSF3R RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated CSF3R expression acts as an unfavorable survival marker, although some lineages such as HNSC and SKCM show a favorable association.

HNSC, SKCM, and LGG are the cancer types where CSF3R RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	III,IV	0.647	0.490	<.001	108	view →
SKCM	OS	Median	All	0.420	0.259	<.001	63	view →
LGG	DFS	Median	All	0.286	0.506	<.001	54	view →
LUSC	OS	Quartile	All	0.707	0.837	.001	49	view →
KIRC	OS	Quartile	All	0.551	0.754	.004	39	view →
STAD	OS	Median	All	0.384	0.702	.001	22	view →
BRCA	OS	Median	III,IV	0.633	0.457	.005	20	view →
LAML	DFS	Tertile	All	0.698	0.363	.010	20	view →
THYM	OS	Median	All	0.785	0.965	.011	17	view →
UVM	DFS	Median	II,III,IV	0.419	0.779	.012	17	view →
UCEC	OS	Tertile	All	0.896	0.947	.003	16	view →
ESCA	OS	Median	All	0.647	1.000	.015	15	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

CSF3R–HNSC (DFS)

Open the HNSC breakdown →