CSF2

Across TCGA patient cohorts, CSF2 mutation is significantly associated with the RNA expression of many other genes, with 55 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible CSF2-associated genes across cancer lineages are AK4P6, POU5F1P5, and CXXC4-AS1. Each is linked with CSF2 in more than 1 cancer types. Because this analysis shows association rather than direction, both CSF2-to-partner and partner-to-CSF2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, AK4P6 grouped by CSF2-low versus CSF2-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CSF2→partner) and Y-score (partner→CSF2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	AK4P6 →	+0.063	+3.564	<.001	.005	3	1
SKCM	POU5F1P5 →	+0.092	+3.353	<.001	.003	3	1
SKCM	CXXC4-AS1 →	+0.030	+3.022	.007	.009	3	1
SKCM	LINC02103 →	+0.597	+3.458	<.001	.003	3	1
SKCM	ALG1L14P →	+0.194	+4.097	<.001	.001	3	1
SKCM	FAM243B →	+0.036	+5.488	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 55 associations by consensus.

AK4P6 by CSF2 expression — SKCM

Explore this box plot interactively →