Q-omics provides the consensus-scored ALG1L14P profile across patient tissues and cancer cell-line models. ALG1L14P expression is associated with patient survival in 20 of 34 cancer types, with the highest sampling consensus in HNSC. Among the 18 cancer types available for tumor–normal comparison, ALG1L14P is differentially expressed in 1, with the highest sampling consensus in COAD. Additionally, ALG1L14P RNA expression shows 3,527 significant pathway-activity associations, with the highest sampling consensus in HNSC. Together, these results highlight HNSC, and COAD as cancer lineages where ALG1L14P shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for ALG1L14P — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes ALG1L14P survival associations across molecular data types. ALG1L14P RNA expression shows survival associations in the most cancer types (20). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible ALG1L14P RNA expression–survival associations across cancer types. High ALG1L14P expression shows unfavorable associations in DLBC, LUAD, THCA and LIHC, but favorable associations in HNSC and CESC. The HNSC Kaplan–Meier curve shows clear separation, with the low-expression group declining faster, consistent with the favorable association (log-rank p = .003). Together, the overview and detailed table identify HNSC as the clearest survival context for ALG1L14P RNA expression.
This table summarizes ALG1L14P tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 1. The strongest signals are observed in COAD for RNA.
This table ranks reproducible tumor–normal expression differences for ALG1L14P. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. ALG1L14P shows higher tumor expression in COAD. The COAD box plot shows higher ALG1L14P RNA expression in tumor versus normal tissue (log2 FC = +0.124, t-test p = .016).
This table shows molecular features associated with ALG1L14P in patient tissues and cancer cell lines. In patient samples, ALG1L14P shows the broadest associations at the RNA and protein expression levels, with HNSC recurring as the lineage with the largest associated feature set.
