CSAD

Across TCGA cell cohorts, CSAD mutation is significantly associated with the RNA expression of many other genes, with 26 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible CSAD-associated genes across cancer lineages are MAGEB5, C9, and VSX2. Each is linked with CSAD in more than 1 cancer types. Because this analysis shows association rather than direction, both CSAD-to-partner and partner-to-CSAD results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MAGEB5 grouped by CSAD-low versus CSAD-high in LUNG_NSCLC_LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CSAD→partner) and Y-score (partner→CSAD) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	MAGEB5 →	+0.033	+4.643	<.001	.008	3	1
BLOOD_Leukemia	C9 →	+0.977	+2.807	<.001	.008	3	1
BLOOD_Leukemia	VSX2 →	+0.027	+3.258	<.001	.007	3	1
BLOOD_Leukemia	DNASE2B →	+0.048	+3.470	.001	.009	3	1
BLOOD_Leukemia	CORIN →	+0.128	+3.371	.004	.005	3	1
BLOOD_Leukemia	NPFFR1 →	+0.015	+3.622	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 26 associations by consensus.

MAGEB5 by CSAD expression — LUNG_NSCLC_LUSC

Explore this box plot interactively →