CRYZL2P-SEC16B

Across TCGA pan-cancer cohorts, CRYZL2P-SEC16B RNA is linked to patient survival in 19 of 34 cancer types, making it the most broadly survival-associated CRYZL2P-SEC16B data layer.

The strongest signal is observed in brain lower grade glioma (LGG), where higher CRYZL2P-SEC16B RNA is associated with worse overall survival. In most high-consensus cancer types, elevated CRYZL2P-SEC16B expression acts as an unfavorable survival marker, although some lineages such as HNSC and KIRC show a favorable association.

LGG, UVM, and HNSC are the cancer types where CRYZL2P-SEC16B RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LGG	OS	Median	All	0.323	0.543	<.001	54	view →
UVM	DFS	Quartile	All	0.294	0.770	.004	44	view →
HNSC	DFS	Tertile	II,III,IV	0.775	0.632	.006	44	view →
KIRC	OS	Quartile	All	0.945	0.846	.007	34	view →
KIRP	DFS	Tertile	All	1.000	0.767	.007	20	view →
THCA	DFS	Tertile	II,III,IV	0.866	0.980	.005	19	view →
CESC	DFS	Median	All	0.437	0.651	.006	18	view →
CHOL	OS	Median	III,IV	0.286	1.000	.008	15	view →
COAD	OS	Tertile	III,IV	0.394	0.713	.025	13	view →
BLCA	DFS	Tertile	All	0.563	0.746	.026	12	view →
UCS	DFS	Tertile	IV	0.956	0.381	.024	12	view →
LIHC	OS	Quartile	III,IV	0.797	0.254	.003	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 19 lineages.

CRYZL2P-SEC16B–LGG (OS)

Open the LGG breakdown →