CRYM

Across TCGA patient cohorts, CRYM mutation is significantly associated with the RNA expression of many other genes, with 571 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CRYM-associated genes across cancer lineages are RNA5SP407, RNA5SP231, and RN7SL616P. Each is linked with CRYM in more than 1 cancer types. Because this analysis shows association rather than direction, both CRYM-to-partner and partner-to-CRYM results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA5SP407 grouped by CRYM-low versus CRYM-high in BLCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CRYM→partner) and Y-score (partner→CRYM) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	RNA5SP407 →	+0.577	+7.640	<.001	.009	3	2
BLCA	RNA5SP231 →	+0.893	+7.640	<.001	.009	3	2
BRCA	RN7SL616P →	+0.172	+5.883	.002	.003	3	2
BRCA	OR51T1 →	+0.184	+7.038	<.001	<.001	3	2
BRCA	RNU6-275P →	+0.685	+6.016	<.001	.002	3	2
COAD	RNU6-960P →	+1.168	+4.666	<.001	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 571 associations by consensus.

RNA5SP407 by CRYM expression — BLCA

Explore this box plot interactively →