CRYM

Across TCGA pan-cancer cohorts, CRYM RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of CRYM’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where CRYM RNA is repressed in tumor relative to normal tissue. In most cancer types CRYM is over-expressed in tumor, although a few such as HNSC and BLCA show the opposite, repressed pattern.

HNSC, BLCA, and KICH are the cancer types where CRYM tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in CRYM RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Female	All	−1.842	<.001	12	view →
BLCA	Male	III,IV	−3.157	<.001	11	view →
KICH	Male	II,III,IV	−2.992	<.001	9	view →
LUSC	Male	II,III,IV	−2.796	<.001	8	view →
THCA	All	All	−0.157	<.001	6	view →
LIHC	All	All	+0.632	.001	5	view →
KIRC	Male	All	−0.887	<.001	4	view →
READ	Male	All	−1.553	.031	3	view →
LUAD	Male	II,III,IV	−1.512	.002	3	view →
UCEC	All	All	+0.638	.032	2	view →
ESCA	Female	All	+0.933	.005	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

CRYM–HNSC

Open the HNSC breakdown →