CRYM

Across TCGA pan-cancer cohorts, CRYM RNA is linked to patient survival in 23 of 34 cancer types, making it the most broadly survival-associated CRYM data layer compared with 6 for mass-spec protein.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher CRYM RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated CRYM expression acts as an unfavorable survival marker, although some lineages such as KIRC and ACC show a favorable association.

KIRC, UVM, and THCA are the cancer types where CRYM RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	DFS	Tertile	All	0.724	0.521	<.001	129	view →
UVM	DFS	Median	All	0.418	0.754	<.001	77	view →
THCA	OS	Tertile	All	0.951	0.995	.002	68	view →
ACC	OS	Median	All	0.920	0.394	<.001	62	view →
MESO	OS	Tertile	II,III,IV	0.487	0.690	.003	46	view →
LUSC	DFS	Tertile	All	0.915	0.662	.003	39	view →
SKCM	OS	Tertile	All	0.323	0.411	.005	23	view →
STAD	DFS	Median	III,IV	0.463	0.701	.019	19	view →
SCLC	DFS	Median	II,III,IV	0.581	0.277	.011	12	view →
ESCA	DFS	Quartile	All	0.507	1.000	.027	12	view →
THYM	DFS	Tertile	All	1.000	0.674	.008	11	view →
CHOL	DFS	Median	IV	0.251	0.794	.010	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

CRYM–KIRC (DFS)

Open the KIRC breakdown →