CRYM

Across TCGA patient cohorts, CRYM mutation is significantly associated with the total protein of many other genes, with 7 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CRYM-associated genes across cancer lineages are ATM, C-Raf_pS338, and 14-3-3_beta. Each is linked with CRYM in more than 2 cancer types. Because this analysis shows association rather than direction, both CRYM-to-partner and partner-to-CRYM results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by CRYM-low versus CRYM-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CRYM→partner) and Y-score (partner→CRYM) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.679	-3.000	.009	.037	1	3
UCEC	C-Raf_pS338 →	-0.114	-3.000	.015	.037	3	1
UCEC	14-3-3_beta →	-0.152	-2.986	.008	.037	2	1
UCEC	MSH2 →	-0.376	-3.000	.004	.037	2	1
UCEC	p90 RSK →	+0.264	+3.013	.017	.019	1	1
UCEC	PI3K-p110-a →	-0.204	-3.000	.045	.037	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

ATM by CRYM expression — UCEC

Explore this box plot interactively →