CRYBB3

Across TCGA cell cohorts, CRYBB3 mutation is significantly associated with the RNA expression of many other genes, with 2 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CRYBB3-associated genes across cancer lineages are KCNG4 and IQCF5. Each is linked with CRYBB3 in more than 1 cancer types. Because this analysis shows association rather than direction, both CRYBB3-to-partner and partner-to-CRYBB3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, KCNG4 grouped by CRYBB3-low versus CRYBB3-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CRYBB3→partner) and Y-score (partner→CRYBB3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	KCNG4 →	+0.004	+4.415	<.001	.007	3	1
LARGE_INTESTINE	IQCF5 →	+0.037	+5.022	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 2 strongest of 2 associations by consensus.

KCNG4 by CRYBB3 expression — LARGE_INTESTINE

Explore this box plot interactively →